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Cyle 1 for Standard medical plan for Lutetium-177 PSMA therapy for prostate cancer and Ga-68 PSMA PET scan

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  • Cyle 1 for Standard medical plan for Lutetium-177 PSMA therapy for prostate cancer and Ga-68 PSMA PET scan
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Step-by-Step Treatment Process

Step 1: Initial Presentation at the Hospital

  • Patient arrives with symptoms: urinary difficulties, bone pain, weight loss, etc.
  • History taking: Previous diagnoses and treatments (e.g., surgery, radiation, hormone therapy), Family history of prostate cancer, Current medications and comorbidities.
  • Physical examination: Digital rectal exam (DRE) to assess prostate size, texture, and nodularity.

Step 2: Review of Medical Records

  • Previous PSA (Prostate-Specific Antigen) levels
  • Imaging results: MRI of the prostate, PET/CT scan (PSMA-based if available)
  • Biopsy reports: Gleason score, Pathology findings
  • Prior treatments & response: Chemotherapy, androgen deprivation therapy (ADT), radiotherapy, etc.

Step 3: Confirming Eligibility for Lu-177 Therapy

  • Indications for Lu-177 PSMA therapy: Metastatic castration-resistant prostate cancer (mCRPC), PSMA-positive disease on PET/CT scan, Disease progression despite ADT and/or chemotherapy
  • Exclusion criteria: Severe renal or liver dysfunction, Low bone marrow reserve (low hemoglobin, WBC, platelets), PSMA-negative tumors
  • Lab tests required before therapy: Complete blood count (CBC), Renal function (Creatinine, eGFR), Liver function tests (LFTs), PSA levels, Alkaline phosphatase (to assess bone metastases)

Step 4: Pre-Treatment Preparation

  • Multidisciplinary team discussion (Oncologists, Nuclear Medicine, Urologists)
  • Patient education: Mechanism of action of Lu-177, Expected benefits and risks, Radiation safety precautions
  • Hydration protocol: IV fluids before and after therapy to protect kidneys

Step 5: Administration of Lu-177 PSMA Therapy

  • Dosage: 6.0–7.4 GBq per cycle
  • Intravenous infusion over 10–20 minutes
  • Outpatient or short hospital stay

Step 6: Post-Treatment Monitoring

  • Immediate post-infusion: Check vitals, hydration, and manage nausea.
  • Radiation precautions: Avoid close contact with children and pregnant women for a few days, Good hydration to help excrete radiation.
  • Follow-up at 2–4 weeks: PSA response assessment, CBC, renal, and liver function tests.

Step 7: Response Evaluation & Repeat Cycles

  • Every 6–8 weeks: Reassess using PSA, PET/CT, and symptom relief, Repeat Lu-177 every 6 weeks (up to 4–6 cycles based on response).
  • Monitor for side effects: Fatigue, Xerostomia (dry mouth), Bone marrow suppression (anemia, thrombocytopenia), Kidney function impairment.

Step 8: Long-Term Follow-Up & Supportive Care

  • Regular PSA and imaging follow-ups
  • Palliative care if needed (pain management, bone health)
  • Consider additional therapies if progression occurs

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💡Important for You

WEGOVITA offers medical coordination services by connecting international patients with top hospitals and specialists across Germany. We support access to expert evaluations, facilitate treatment logistics, and present a range of available medical options.

However, WEGOVITA does not provide direct medical treatment, make medical diagnoses, or recommend specific therapies. All final medical decisions—including diagnosis, treatment planning, and cost—are made solely by licensed medical professionals after a full clinical assessment of the individual patient.

This information is provided for informational purposes, based on internationally recognized guidelines and practices used in Germany’s leading medical institutions. It is not a substitute for professional medical advice.

💡 Interested in clinical trial references, treatment innovations, or cost comparisons? Contact our medical coordination team at info@wegovita.com for personalized assistance.

Your Health. Your Journey. With WEGOVITA.